生物活性

• 描述Eltrombopag olamine is an orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01830660	Healthy	Phase 1	Completed	-	China, Sichuan ... more >> West China Hospital, Sichuan University Chengdu, Sichuan, China Collapse <<
  NCT02158936	Thrombocytopaenia	Phase 3	Terminated	-	-
  NCT01957176	Thrombocytopaenia	Phase 4	Active, not recruiting	January 1, 2024	Argentina ... more >> Novartis Investigative Site La Plata, Buenos Aires, Argentina, B1900AXI Belgium Novartis Investigative Site Leuven, Belgium, 3000 China Novartis Investigative Site Shanghai, China, 200025 France Novartis Investigative Site Paris Cedex 12, France, 75571 Greece Novartis Investigative Site Athens, Greece, 11527 Novartis Investigative Site Heraklion, Crete, Greece, 71201 Hong Kong Novartis Investigative Site Shatin, Hong Kong Hungary Novartis Investigative Site Debrecen, Hungary, 4012 Ireland Novartis Investigative Site Tullamore, Ireland Israel Novartis Investigative Site Tel Aviv, Israel, 64239 Korea, Republic of Novartis Investigative Site Seoul, Korea, Republic of, 136-705 Netherlands Novartis Investigative Site Amsterdam, Netherlands, 1081 HV Peru Novartis Investigative Site San Isidro, Lima, Peru, Lima 27 Poland Novartis Investigative Site Chorzow, Poland, 41-500 Romania Novartis Investigative Site Bucharest, Romania, 022328 Tunisia Novartis Investigative Site Montfleury, Tunisia, 1008 Novartis Investigative Site Sousse, Tunisia, 4000 Collapse <<

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• 参考文献

• [1] Erickson-Miller CL, Kirchner J, et al. Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag. Leuk Res. 2010 Sep;34(9):1224-31.

  [2] Erickson-Miller CL, Delorme E, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30.